北京治疗手足癣好医院 https://m-mip.39.net/czk/mipso_8833740.htmlTODAY今日发布CirculationEarlyRecent,July30,今日发布01篇CirculationResearchEarlyRecent,July30,今日发布03篇ATVBEarlyRecent,July30,今日发布03篇JAMAEarlyRecent,July29,今日发布04篇JAMACardiologyEarlyRecent,July29,今日发布08篇NEJMJuly30,:(5)今日发布27篇EClinicalMedicineEarlyRecent,July30,今日发布01篇CATHETERCARDIOINTEEarlyRecent,July29,今日发布03篇ClinicalCardiologyEarlyRecent,July29,今日发布02篇ExperimentalPhysiologyAug01,:(8),-今日发布25篇JournalofClinicalUltrasoundEarlyRecent,July30,今日发布01篇TheJournalofPhysiologyAug01,:(15),-今日发布22篇Neuromodulation:TechnologyattheNeuralInterfaceEarlyRecent,July29,今日发布01篇RECOMMEND推荐阅读01慢性应激时心脏的高分辨率转录组学分析揭示了心肌纤维化和肥大的细胞驱动因素Circulationresearch-articleMichealA.McLellan,DanielA.Skelly,etc.2小时前等51用户推荐阅读本文Background:Cardiacfibrosisisakeyantecedenttomanytypesofcardiacdysfunctionincludingheartfailure.Physiologicalfactorsleadingtocardiacfibrosishavebeenrecognizedfordecades.However,thespecificcellularandmolecularmediatorsthatdrivecardiacfibrosis,andtherelativeimpactofdisparatecellpopulationsoncardiacfibrosis,remainunclear.心脏纤维化是包括心力衰竭在内的许多类型心脏功能不全的一个重要前因。导致心脏纤维化的生理因素已经被认识到几十年了。然而，驱动心脏纤维化的特定细胞和分子介质，以及不同细胞群对心脏纤维化的相对影响仍然不清楚。Methods:Wedevelopedanovelcardiacsingle-celltranscriptomicsstrategytocharacterizethecardiaccellulome—thenetworkofcellsthatformstheheart.ThismethodwasutilizedtoprofilethecardiaccellularecosysteminresponsetotwoweeksofcontinuousadministrationofAngiotensinII,apro-fibroticstimuluswhichdrivespathologicalcardiacremodeling.我们开发了一种新的心脏单细胞转录组学策略来描述心脏细胞组——构成心脏的细胞网络。这一方法被用来描述心脏细胞生态系统对连续给药血管紧张素II的反应，血管紧张素II是一种促纤维化的刺激物，可以驱动病理性心脏重构。Results:Ouranalysisprovidesa